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Injury to the bone in these patients via tooth extraction, dental surgery, or mechanical trauma is thought to initiate bisphosphonate-related osteonecrosis of the jaw (BRONJ).
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Bone biopsies from patients at ten years show very low bone formation rates.
The authors noted that the type of governmentsponsored insurance could not be identified through the survey, but past data suggest Medicaid patients may have worse outcomes.
Other serious side effects associated with bisphosphonates include osteonecrosis (death of bone cells) of the jaw.
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The most robust skeletal anabolic effects are seen in patients who receive initial PTH treatment and are subsequently maintained with bisphosphonate therapy.
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Clearly, more studies examining the potential relationship between bisphosphonate use and atrial fibrillation are warranted, as are focused discussions between clinicians and patients either currently managed with or considering initiation of bisphosphonate treatment.
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