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I took 200mg 1 per day, for osteoarthritis in my hands. The pain relief was amazing. I could sleep through the night, and wake rested, and was thrilled to have nearly pain free use of my hands. After 1 week I began to develop an irregular heartbeat. First day, it wasn't too noticeable, and I was able to ignore the feeling. The irregularity increased, that night it was difficult to sleep. Next day I spoke to the doctor who did an EKG. He said I was having Premature Ventricular Contractions (PVC). He advised I stop taking the Celebrex immediately. It took 4 days for the PVCs to subside. After waiting 2 weeks, I tried taking Celebrex again. After 3 days, the PVCs returned. Stopped the medicine, PVCs stopped.
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I've had two bad knee surgeries and was left option-less by my orthopedist so I left and went to a pain doctor. I was prescribed Celebrex after trying nearly all the other NSAIDs and have taken it for 6 months. I'm not painless, but it has worked miracles from where I was, and I know when I've forgotten to take it.

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Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor blockers (eg, valsartan), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Celebrex.

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