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According to current guidelines, β-blockers should be the first-line preventive treatment of AF in patients having cardiac surgery.

This preferential effect is not absolute, however, and at higher plasma concentrations, Metoprolol also inhibits beta 2-adrenoreceptors, chiefly located in the bronchial and vascular musculature.

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March 6, 2007 issue of The Journal of the American College of Cardiology, detailed that patients with heart failure who received carvedilol suffered fewer heart attacks and strokes and were less likely to die of these and other vascular events than patients prescribed another beta blocker, metoprolol tartrate.

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If you also take certain drugs to lower your (bile acid-binding resins such as or ), take this product at least 4 hours before or at least 4 to 6 hours after these medications.

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