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Chromosomal rearrangement of ALK occurs in about 5% of NSCLC cases.
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This may be a matter of chance, but is more likely due to the expanding clone having a competitive advantage (either a reproductive or survival advantage) over other cells in the tissue.
Potential prognostic factors such as gender, age, histology, PS, response to previous chemotherapy, and number of prior chemotherapy regimens were examined.
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He postulated that this could be accomplished by restricting the number of stem cells for example at the base of intestinal crypts and restraining the opportunities for competition between cells by shedding differentiated intestinal cells into the gut.
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The protocol was approved by the Institutional Review Board, and fully informed written consent was obtained for all cases.
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Despite impressive clinical successes with different kinase-targeted therapies, most, if not all, patients with cancer with an initially responsive disease eventually experience relapse as a result of acquired drug resistance to these agents.
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This patient, a 32-year-old man with no history of smoking, presented with multiple brain lesions and bronchoalveolar carcinoma in the right lung.
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The primary outcomes of interest were the correlations between EGFR mutation or ALK rearrangement and benefit from EGFR or ALK TKI therapies, respectively.
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In this scale, individual symptoms were documented prior to treatment, and at subsequent assessment each symptom was recorded as being either (a) worse, (b) unchanged, (c) improved or (d) resolved.
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También se agregó que, de manera similar al análisis de la supervivencia sin avance (SSA), la SG se estratificó según el tipo de mutación en EGFR y el origen étnico.
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