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Year in review 2010: Tuberculosis, pleural diseases, respiratory infections.

Cost-effectiveness of novel algorithms for rapid diagnosis of tuberculosis in HIV-infected individuals in Uganda.

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Short-course chemotherapy, including INH, rifampin (for 6 mo), PZA, and ethambutol or streptomycin, is given for at least 2 mo (or until sensitivities are known or until serial sputums are clear) followed by 3 more months of therapy with INH.

Hypersensitivity reactions and liver toxicity attributed to isoniazid.

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Other central nervous system side effects reported have included drowsiness, fatigue, ataxia, dizziness, decreased concentration, mental confusion, behavioral changes, muscular weakness, pain, and numbness.

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Side effects of taking Rifampicin may be difficult to isolate since the antibiotic is commonly used as part of a “cocktail” that includes other medications to treat infections like MRSA.

Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin.

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Major side effect is reduced visual acuity; initial sign may be decreased ability to perceive green.

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Daily doses of RIFAMATE, because it contains rifampin, should be given at least 1 hour before the ingestion of antacids.

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It is always used in combination with other antibiotics because resistance develops rapidly when it is used alone.

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Following the initial phase, treatment should be continued with rifampin and isoniazid (e.

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Decreases in serum concentrations caused by rifampin raise concerns about the efficacy of nevirapine-based antiretroviral therapy during rifampin-based tuberculosis treatment.

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The other function is the production of pheromones (), also involved in conjugation of plasmids and transposons in gram-positive bacteria.

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On the basis of clinical observations of patients in whom digoxin levels decreased considerably when treated with rifampin, we hypothesized that concomitant rifampin therapy may affect digoxin disposition in humans by induction of P-gp.

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The poor response of the rifampin-β-lactam antibiotic combination was due mostly to the emergence of methicillin-resistant CoNS subpopulations ().

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Patients should be informed that rifampin may cause a brownish-red or orange discoloration of urine, tears, feces, saliva, sputum, and sweat.

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No patient had documented acquisition of medication resistance in follow-up TB cultures while on treatment.

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In this sense, the overuse of antibiotics may have reduced the overall pathogenicity of certain organisms.

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Purified protein derivative testing should be targeted at these groups and at persons with known or suspected exposure to active tuberculosis.

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Common side effects are fatigue, anorexia, gastrointestinal upset, arthralgias, rash and photosensitivity.

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Rifampin is not indicated for the treatment of meningococcal infection because of the possibility of the rapid emergence of resistant organisms.

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The apremilast exposure in elderly subjects (65 to 85 years of age) was about 13% higher in AUC and about 6% higher in C max than in young subjects (18 to 55 years of age).

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Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

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