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Anemias directly related to the cancer, which produces chemicals, such as cytokines, or anemias due to bone marrow infiltration by lymphomas or cancers.

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The introduction of recombinant human erythropoietin in the late 1980s drastically changed the treatment of anemia in patients with CKD.

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Four of these deaths occurred during the period of study drug administration and all four deaths were associated with thrombotic events.

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Should extraordinary erythropoiesis happen, suitable treatment shall be taken such as temporary stopping use of Epoetin Alfa.

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