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Nci Drug Dictionary It works by changing the actions of chemical substances in your mind. It blocks the results of the naturally occurring chemical histamine in your body. Every effort has been made to make sure that the data offered by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and full, however no assure is made to that impact. Drug information contained herein could also be time delicate. Phenothiazines have been reported to disrupt the physique's capacity to reduce core body temperature presumably by way of effects in the hypothalamus, they usually predispose patients to hyperthermia.Thermoregulation is multi-factorial; however, the dopaminergic system seems to have a main position, and serotonin may also have modulatory exercise (5-HT2a receptors).A much less regularly described alteration in thermoregulatory processes reported with phenothiazines is hypothermia.Promethazine is a medication with antihistaminic properties and a phenothiazine-based mostly chemical structure. Cheap promethazine walmart. promethazine What Do I Do If I Miss A Dose? The warning label additionally recommends that promethazine should be administered with caution and on the lowest efficient dose in youngsters 2 years of age and older. In anesthesia practice you will need to inject promethazine only via a well-established and safe IV line promethazine or infuse the drug diluted in saline resolution. A severe complicated known as neuroleptic malignant syndrome can happen in patients receiving phenothiazines. Cheap promethazine without rx.