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When should I take hormone replacement therapy? More detail is in the main article. Hormone replacement therapy is an effective way to relieve symptoms of perimenopause and menopause. It can reduce the incidence and severity of hot flashes, and also the risk of osteoporosis.
Why does progesterone cause spotting? Progesterone breakthrough bleeding occurs when the progesterone -to-estrogen ratio is high, such as occurs with progesterone -only contraceptive methods. The endometrium becomes atrophic and ulcerated because of a lack of estrogen and is prone to frequent, irregular bleeding.